I tried everything to control my dog's bad skin rash on his belly and hind legs. I had him on Benedryl for the intense itching but it just made him lethargic and drugged out. He was losing big patches of fur and the mange was spreading. So I gave Septiderm a chance and his skin started to clear up overnight. It's not so deep red like before. He still has the rash and will be seeing a vet soon, but so far this stuff has been very positive for him. He's loving the soothing effects of it and it really calms him down. I highly recommend this great lotion!