My dog has separation anxiety issues, and I use a mobile groomer instead of leaving him at a grooming shop. He gets 2 tablets a day, usually mid-day, especially if we're going out, and on grooming day he gets them in the morning, about an hour before his appt. He is perfectly calm and well-behaved throughout his appt! I even gave some to my mother-in-law for her pug before the annual Christmas party - Her one dog is a maniac, jumping all over everyone, etc., but she was much better this year!